Anthony (Tony) Kozielski

Education

• B.S.,  Biology, University of Houston, Houston, TX 1979

Area of Interest

• Camptothecin Project

Current Position

• Section Supervisor, Chemotherapy Department, CHRISTUS Stehlin Foundation

Representative Publications

Z. Cao, A. Kozielski, X. Liu, Y. Wang, D. Vardeman and B. Giovanella.  Crystalline Camptothecin-20(S)-O-Proprionate Hydrate: A Novel anticancer Agent with Strong Activity Against 19 Human Tumor Xenografts. 2009.  Cancer Res. 69:4742-4749

Zhisong Cao, Panayotis Pantazis, John Mendoza, Janet Early, Anthony Kozielski, Nick Harris, Beppino Giovanella. 2003. Structure-Activity
Relationship of Alkyl 9-Nitrocamptothecin Esters. Acta Pharmacoligica Sinica 24(2):109-119

Cao, Z., P. Pantazis, J. Mendoza, J. Early, A. Kozielski, N. Harris, J. Liehr, J. Stehlin and
B. Giovanella.  Structure-activity relationship of alkyl 9-nitrocamptothecin esters.  2001. Recent
Res Develop in Med Chem. 1:157-171

Potmesil M., Dana Vardeman, Anthony J. Kozielski, John Mendoza, John S. Stehlin and    Beppino C. Giovanella.  1995.  Growth Inhibition of Human Cancer Metastases by Camptothecins in Newly Developed Xenograft Models.  Cancer Res. 55: 5637-5641

Verschraegen, C.F., J.T. Mendoza, A.J. Kozielski, and B.C. Giovanella. 1995. Modulation of the Response to Chemotherapy in a Human Melanoma Clone by the Site of Growth in the Nude Mouse.  Anticancer Res. 15:9-12

Pantazis, P., Vardeman, D., Mendoza, J., Early, J., Kozielski, A., DeJesus, A., and Giovanella, B.  1995. Sensitivity of camptothecin resistant human leukemia cells and tumors to anticancer drugs with diverse mechanisms of action.  Leukemia Res. 19:43-55

Pantazis, P., Early, J.A., Kozielski, A.J., Mendoza, J.T., Hinz, H.R., and Giovanella, B.C. 1993. Regression of human breast carcinoma tumors in immunodeficient mice treated with 9-nitro-camptothecin: Differential response of nontumorigenic and tumorigenic human breast cells in vitro.  Cancer Res. 53:1577-1582

Pantazis, P., Kozielski, A.J., Mendoza, J.T., Early, J.A., Hinz, H.R., and Giovanella, B.C. 1993.   Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between nontumorigenic and tumorigenic cells in vitro.  Intl J Cancer 55:863-871

Pantazis, P., Mendoza, J.T., Kozielski, A.J., Natelson, E.A., and Giovanella, B.C. 1993.  9-nitro-camptothecin delays growth of U-937 leukemia tumors in nude mice and is cytotoxic or cytostatic for human myelomonocytic leukemic lines in vitro.  Eur J Haem.50:81-89

Pantazis, P., Hinz, H.R., Mendoza, J.T., Kozielski, A.J., Williams, L.J., Stehlin, J.S., and Giovanella, B.C. 1992.  Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins.  Cancer Res. 52:3980-3987