Beppino C. Giovanella, Ph.D.

Education

• Ph.D., Biology, University of Rome, 1955
• Ph.D., Pathology, University of Rome, 1962

Post-doctoral Training

• Cancer Institute, Regina Elena, Rome, Italy, 1956-60
• McArdle Laboratory, Madison, Wisconsin, 1960-62

Area of Interest

• Chemotherapy of Cancer (Preclinical)
• Hyperthermia Treatment of Cancer/Experimental
• Xenotransplantation of Cancer

Current Position

• Laboratory Director, CHRISTUS Stehlin Foundation

Professional Positions Held

• Associate Professor of Pharmaceutics, College of Pharmacy, University of Houston, TX,1995-present
• Research Associate in Oncology, McArdle Laboratory, University of Wisconsin, Madison, WI, 1963-1970
• Research Fellow, Cancer Institute Regina Elena, Rome, Italy, 1956-1960

Professional Organization Memberships

• American Association  for Cancer Research
• American Association for the Advancement of Science
• American Society for Investigative Pathology
• American Association of Pharmaceutical Sciences
• Tissue Culture Association
• New York Academy Science/American Association Animal Science

Representative Publications

Z. Cao, J. Mendoza, A. Kozielski, X. Liu, A. DeJesus, Y. Wang, CG Zhan, D. Vardeman, B. Giovanella. Anticancer Activity of New Haloalkyl Camptothecin Esters against Human Cancer Cell Lines and Human Tunor Xenografts Grown in Nude Mice. 2012. Anti-Cancer Agents in Medicinal Chemistry 12:818-828

X. Liu, A. DeJesus, Z. Cao, D. Vardeman, B. Giovanella. Metabolic Differences of CZ48 in Human and Mouse Liver Microsomes. 2012. Int. J. Mol. Sci. 2012, 13, 5498-5505; doi:10.3390/ijms13055498

Z. Cao, A. Kozielski, N. Harris, D. Vardeman, B. Giovanella. Sulfuric Acid Catalyzed Preparation of Alkyl and Alkenyl Camptothecin Ester Derivatives and Antitumor Activity against Human Xenografts Grown in Nude Mice. 2012. Open Journal of Medicinal Chemistry 2:10-14.

Z. Cao, A. Kozielski, X. Liu, Y. Wang, D. Vardeman and B. Giovanella. 2009. Crystalline Camptothecin-20(S)-O-Proprionate Hydrate: A Novel Anticancer agent with Strong Activity Against 19 Human Tumor Xenografts.  Cancer Res 69: 4742-4749

B.C. Giovanella, N. Harris, J. Mendoza, Z. Cao, J. Liehr, and J.S. Stehlin. 2000.  Dependence of Anticancer Activity of Camptothecins on Maintaining Their Lactone Function.  Annals New York Academy of Sciences 922: 27-35

S.S. Daoud, M.I. Fetouh, and B.C. Giovanella. 1995. Antitumor effect of liposome incorporated camptothecin in human malignant xenografts.  Anti-Cancer Drugs 6:83-93

B.C. Giovanella, D.M. Vardeman, L.J. Williams, D.J. Taylor, P.D. de Ipolyi, P.J. Greeff, J.S. Stehlin, D.J. Slamon, R. Cailleau and H.E. Gary.  1991. Heterotransplantation of Human Breast Carcinomas in Nude Mice: Correlation Between Nude Takes, Poor Prognosis and Overexpression of the HER-2/neu Oncogene.  Int J Cancer 47: 66-71

B.C. Giovanella, J.S. Stehlin, M.E. Wall, M.C. Wani, A.C. Nicholas, L.F. Liu, R. Silber and M. Potmesil.  1989.  DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts.  Science 246: 1046-1048

B.C. Giovanella, J.S. Stehlin and S.O. Yim.  1980. Correlation of the thermosensitivity of cells to their malignant potential.  Ann. New York Acad. Sci. 4: 206-214

B.C. Giovanella, J.S. Stehlin and A.C. Morgan. 1976. Selective lethal effect of supranormal temperatures on human neoplastic cells.  Cancer Res. 36: 3944-3950

B.C. Giovanella, A.C. Morgan, J.S. Stehlin and L.J. Williams.  1973. Selective lethal effect of supranormal temperatures on mouse sarcoma cells.  Cancer Res. 33: 2568-2578

B.C. Giovanella and J.S. Stehlin. 1973.  Heterotransplantation of human malignant tumors in “nude” thymusless mice.  I. Breeding and maintenance of “nude” mice.  J Natl Cancer Inst. 51: 615-619

B.C. Giovanella, S.O. Yim, J.S. Stehlin and L.J. Williams, Jr.  1972. Development of invasive tumors in the “nude” mouse after injection of cultured human melanoma cells.  J Natl Cancer Inst. 48: 1531-1533

R. Cavaliere, E.C. Ciocatto, B.C. Giovanella, C. Heidelberger, R.O. Johnson, M. Margottini, B. Monvodi, G. Moricca and A. Rossi-Fanelli.  1967. Selective heat sensitivity of cancer cells – biochemical and clinical studies.  Cancer 20: 1351-1381