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During
the past 31 years, the CHRISTUS Stehlin Foundation for Cancer Research
and the Stehlin & deIpolyi Oncology Clinic have pioneered
some notable firsts which have established their reputations
internationally as premier cancer research and treatment facilities.
Some of their accomplishments include:
Stehlin
Foundation surgeons in 1970 were among the first in North
America to recommend conservative treatment of selected breast
cancer patients with a combination of partial mastectomy (lumpectomy)
and immediate reconstruction, followed by radiotherapy.
Unlike
the vast majority of cancer research conducted on tumors
arising in laboratory animals, all laboratory work of the
CHRISTUS Stehlin Foundation is conducted on cancers removed
from patients. To our knowledge, we are the only research
laboratory in the world limiting its investigations to human
cancers.
The
CHRISTUS Stehlin Foundation pioneered the development and
use of the nude mouse in cancer research, establishing that
if an anticancer drug works against a human tumor implanted
in the nude mouse, 85% of the time the drug will also be
effective in treating human patients. As a result of our
successful work over a period of more than 25 years, the
nude mouse now represents the final non-human studies required
by the National Cancer Institute for determining the effectiveness
of potential anticancer agents.
Dr.
Stehlin was the first to combine heat (hyperthermia) and chemotherapy
for the treatment of advanced melanoma of the arms and legs,
resulting in a 300% increase in survival rates and virtually
eliminating the need for amputation.
The
CHRISTUS Stehlin Foundation was among the first to recognize
the importance of addressing the psychological needs of
cancer patients, establishing the Living Room at St. Joseph
Hospital in 1980, "the Living Room" quickly became
a prototype for cancer treatment centers around the world..
The
CHRISTUS Stehlin Foundation conducted one of the largest
studies of liver cancer ever reported in the medical literature.
The study, published in The Annals of Surgery in 1988, involved
414 of our patients.
Our
physicians were the leaders in the development of regional
intra-arterial chemotherapy, in which large concentrations
of anticancer drugs can be delivered directly to specific
organs or areas of the body affected by cancer.
The
CHRISTUS Stehlin Foundation for Cancer Research was the
first in the country to test the promising new anticancer
drug, Camptothecin, in human clinical trials. Having pioneered
research and development of Camptothecin and several of
its derivatives in the late 1980's, CHRISTUS Stehlin Foundation
research scientists were also among an international group
of scientists who resurrected interest in the camptothecins
after a 20-year hiatus.
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