Yang Wang, Ph.D.

Education

Ph. D., Botany, Northeast Forestry University, China 2000
MS, Organic Chemistry, Heilongjiang University, China 1996
BS, Chemistry, Northeast Normal University, China 1993

Post-doctoral Training

Northeast Forestry University, China, 2000-2002
CHRISTUS Stehlin Foundation for Cancer Research, 2002-2003
The University of Texas Medical Branch, 2002-2003

Area of Interest

Drug Development
Plant Natural Products
Targeted Drug Delivery

Current Position

Research Scientist, CHRISTUS Stehlin Foundation

Representative Publications

Z. Cao, J. Mendoza, A. Kozielski, X. Liu, A. DeJesus, Y. Wang, CG Zhan, D. Vardeman, B. Giovanella. Anticancer Activity of New Haloalkyl Camptothecin Esters against Human Cancer Cell Lines and Human Tunor Xenografts Grown in Nude Mice. 2012. Anti-Cancer Agents in Medicinal Chemistry 12:818-828

Jian Zheng, Honghong Guo, Na Guo, Wei Ma, Lijia Jing, Rui Zhang, Zhifei Dai, Xiufeng Yan, Yang Wang* and Zhenyue Wang*. A two-step pH-dependent liquid-liquid extraction combined with HPLC-fluorescence method for the determination of 10-hydroxycamptothecin in mouse liver tissue. Pharmaceutical Biology, accepted.

Shenglei Guo, Jian Zheng, Jing Dong, Na Guo, Lijia Jing, Xiuli Yue, Xiufeng Yan, Yang Wang*, Zhifei Dai*. 2011. Iron/dextran sulphate Multilayered Microcapsules for controlled Release of 10-Hydroxycamptothecin. International Journal of Biological Macromolecules, 49(3): 409-415.

Honghong GUO, Jian ZHENG, Lijia JING, Siyang LI, Xiufeng YAN, Yang WANG*. 2011. Development and validation of a reversed-phase HPLC method for the determination of 10-hydroxycamptothecin in mouse plasma. China Pharmacy, 22(1):13-15.

Wei-min DING, Dan ZHOU, Tao YU, Jing-shu HUANG, Xiu-feng YAN, Yang WANG*. 2010. Optimization of Ultrasound-assisted Extraction of Betulin Using Uniform Design. Chemistry and Industry of Forest Products, 30(3): 78-82.

Jian Zheng, Xiuli Yue, Zhifei Dai, Yang Wang, Shaoqin Liu, Xiufeng Yan. 2009. Novel iron–polysaccharide multilayered microcapsules for controlled insulin release. Acta Biomaterialia, 5: 1499–1507.

Cao Z, Kozielski A, Liu X, Wang Y, Vardeman D, and Giovanella B. 2009. Crystalline camptothecin-20(S)-O-propionate hydrate: A novel antitumor agent with strong activity against 19 human tumor xenografts. Cancer Research, 694742-4749.

Xing Liu, Yang Wang, Zhisong Cao, and Beppino Giovanella. 2008. Development and Validation of a Reverse-Phase HPLC with Fluorescence Detector Method for Simultaneous Determination of CZ48 and Its Active Metabolite Camptothecin in Mouse Plasma. Journal of Chromatography B, 867: 84-89.

Yang WANG, Yu-da NIU, Gui-feng LIU. 2007. Determination of Deoxyschizandrin and Schisandrin B in Schisandra chinensis (Tuecz.) Baill. by HPLC. Chemistry and Industry of Forest Products, 27(1): 85-88.

Yang WANG, Tao YU, Xiu-feng YAN. 2006. Determination of contents of salidroside and tyrosol in Rhodiola roots by HPLC. Chemistry and Industry of Forest Products, 26(3): 51-54.

Yang Wang, Xiufeng Yan. Study on Camptothecin in Camptotheca acuminata seedlings. Harbin: Northeast Forestry University Publish. 2006

Yang Wang, Yu-Hong Zhang, Xiu-Feng Yan, Tao Yu. 2005. Distribution of berberine content in the stem of corktree saplings. Plant Physiology Communications, 41(1): 87-89.

Yang Wang, Xiu-feng Yan, Yu-hong Zhang, Tao Yu, Mei-fang Ma, Huan-yong Wei. 2005. Determination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata seeds by HPLC. Chemistry and Industry of Forest Products, 25(3): 63-66.

Yang Wang, Shao-Jun Dai, Xiu-Feng Yan. 2004. Effects of light intensity on secondary metabolite camptothecin production in leaves of Camptotheca acuminata seedlings. Acta Ecologica Sinica, 24(6): 1118-1122.

Yang Wang, Xin-Hai Shang, Xiu-Feng Yan. 2003. Effects of N levels on Growth and Salidroside Content in Rhodiola sachalinensis. Journal of Plant Physiology and Molecular Biology, 29(4): 357-359.

Yang Wang, Tao Yu, Yu-hong Zhang, Yuan-gang Zu. 2001. A new process to extract camptothecin from leaves of Camptotheca acuminata. Chinese traditional and herbal drugs, (10): 882-884.

Yang Wang, Tao Yu, Hui-Yan Gu, Bin Tan, You-quan Xing, Yuan-gang Zu. Study on chemical utilization of birch bark, The proceedings of the 1st International Symposium on Birch Wood Utilization, 2001, pp176-180.

Yang Wang, Pu Zhang, Tao Yu, Hua-tian Wang, Xiu-feng Yan. 2001. Study on the method for determination of salidroside By HPLC. Bulletin of Botanical Research, 21(1): 113-115..

Yang Wang, Tao Yu, Yu-hong Zhang, Yuan-gang Zu. 2000. Study on Extraction of Camptothecin by NAOH aq. from Fruits of Camptotheca acuminata. Bulletin of Botanical Research, 20(4): 433-437.