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Dana Vardeman


  • B.S.,  Biology, Southern Methodist University, Dallas, Texas 1974

Current Position

  • Laboratory Supervisor, CHRISTUS Stehlin Foundation

Area of Interest

  • Treatment of Heterotransplanted Brain Tumors in Nude Mice
  • Bioluminescense in Tumor Xenografts

Professional Organization Memberships

  • American Association for Laboratory Animal Science

Representative Publications

Z. Cao, J. Mendoza, A. Kozielski, X. Liu, A. DeJesus, Y. Wang, CG Zhan, D. Vardeman, B. Giovanella. Anticancer Activity of New Haloalkyl Camptothecin Esters against Human Cancer Cell Lines and Human Tunor Xenografts Grown in Nude Mice. 2012. Anti-Cancer Agents in Medicinal Chemistry 12:818-828

X. Liu, A. DeJesus, Z. Cao, D. Vardeman, B. Giovanella. Metabolic Differences of CZ48 in Human and Mouse Liver Microsomes. 2012. Int. J. Mol. Sci. 2012, 13, 5498-5505; doi:10.3390/ijms13055498

Z. Cao, A. Kozielski, N. Harris, D. Vardeman, B. Giovanella. Sulfuric Acid Catalyzed Preparation of Alkyl and Alkenyl Camptothecin Ester Derivatives and Antitumor Activity against Human Xenografts Grown in Nude Mice. 2012. Open Journal of Medicinal Chemistry 2:10-14.

Z. Cao, A. Kozielski, X. Liu, Y. Wang, D. Vardeman and B. Giovanella.  Crystalline Camptothecin-20(S)-O-Proprionate Hydrate: A Novel anticancer Agent with Strong Activity Against 19 Human Tumor Xenografts. 2009.  Cancer Res. 69:4742-4749

Z. Cao, J. Mendoza, A. DeJesus, D. Vardeman and B. Giovanella.  Synthesis and Antitumor Activity of Aromatic Camptothecin Esters.  2008.  Intl J Mo. Med. 21: 477-4878

X. Liu, Y. Wang, D. Vardeman,  Z. Cao and B. Giovanella.  Development and validation of a reverse-phase HPLC with fluorescence detector method for simultaneous determination of CZ48 and its active metabolite camptothecin in mouse plasma.  2008. J of Chrom. B 867:84-89

Markides C, Kozielski A, Breaux S, Vardeman D, and Beppino Giovanella. 2004. Reduced toxicity of 9-Nitrocamptothecin 20(S) propionate ester in female nude mice compared to male nude mice.  Proc Amer Assoc Cancer Res 45,

B.C. Giovanella, J.S. Stehlin, H.R. Hinz, A.J. Kozielski, N.J. Harris and D.M. Vardeman. 2002. Preclinical evaluation of the anticancer activity and toxicity of 9-nitro-20(S)-camptothecin (Rubitecan).  Intl  J Oncol. 20: 81-88

Zhisong Cao, Nick Harris, Anthony Kozielski, Dana Vardeman, and Beppino Giovanella.  1998. Alkyl esters of camptothecin and 9-nitrocamptothecin: synthesis, in vitro pharmacokinetics, toxicity, and antitumor activity.  J Med Chem. 41:31-37

Potmesil M., Dana Vardeman, Anthony J. Kozielski, John Mendoza, John S. Stehlin and    Beppino C. Giovanella.  1995.  Growth Inhibition of Human Cancer Metastases by Camptothecins in Newly Developed Xenograft Models.  Cancer Res. 55: 5637-5641

P. Pantazis, D. Vardeman, J. Mendoza, J. Early, A. Kozielski, A. DeJesus, and B.Giovanella. 1995. Sensitivity of Camptothecin Resistant Human Leukemia Cells and Tumors to Anticancer Drugs with Diverse Mechanisms of Action. Leukemia Res. 19: 43-55

P. Pantazis, A.J. Kozielski, D.M. Vardeman, E.R. Petry and B.C. Giovanella. Efficacy of Camptothecin Congeners in the Treatment of Human Breast Carcinoma Xenografts.  1994.  Oncology Res. 5: 273-281

Potmesil M, Vardeman D, Kozielski AJ, Mendoza J, Stehlin JS and Giovanella BC. 1995.  Growth inhibition of human cancer metastases by camptothecins in newly developed xenograft models. Cancer Res. 55(23):5637-41

Giovanella BC, Vardeman DM, Williams LJ Jr., Taylor DJ, de Ipolyi PD, Greeff PJ, Stehlin JS, Ullrich A, Cailleau R, Slamon DJ, Cailleau R and Gary HE.  1991.  Heterotransplantation of human breast carcinomas in nude mice: correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene. Int J Cancer 47(1):66-71

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CHRISTUS Stehlin Foundation for Cancer Research

10301 Stella Link Road, Suite A
Houston, Texas 77025-5447

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